Citazione:

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Endonuclease I is a 12kDa protein encoded by the endA gene of E. coli. This protein degrades double-stranded DNA and can reduce the stability of plasmid preparations if contaminating levels of this endonuclease are substantial 4 . Many E. coli strains carry a mutation in the endA gene that inactivates Endonuclease I. These strains are referred to as EndA negative (EndA - ) and are preferable hosts when preparing plasmid DNA.

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